Pathophysiological relation between the systemic inflammation and the state of small airways in mild asthma with obesity

The aim of present study was to establish the relationship between level blood serum cytokines and indexes pulmonary function as well identify markers evolving dysfunction small airways in obese patients with partially controlled mild bronchial asthma. We have examined 53 asthma clinical course complicated obesity (I-II degree). control group consisted 25 healthy volunteers. All participants underwent spirometry, bodyplethysmography. Tumor necrosis factor alpha (TNFα), interferon gamma (IFNγ), interleukins (IL) IL2, IL-4, IL-6, IL-10, IL-17A were determined serum. In asthma, an increase by 55.8%, IL-4 44.9% detected, regardless body mass. According results cluster analysis, two sub-groups discerned, depending on state levels pro- anti-inflammatory cytokines. shown be accompanied hypercytokinemia being more common predominant Th1-and Th17-immune responses. revealed association IL-17A, IL-6 functional indices reflecting airways, correlation IFNγ obstruction. features found dependent cytokine status obesity. Two immuno-functional variants identified, differing activity systemic inflammation, type immune response, airways. relationships allow us consider associated